磷霉素单独及联合使用时对耐甲氧西林金黄色葡萄球菌的体外活性。
In vitro activity of fosfomycin, alone and in combination, against methicillin-resistant Staphylococcus aureus.
作者信息
Alvarez S, Jones M, Berk S L
出版信息
Antimicrob Agents Chemother. 1985 Nov;28(5):689-90. doi: 10.1128/AAC.28.5.689.
Abstract
We tested 148 strains of clinical isolates of methicillin-resistant Staphylococcus aureus against fosfomycin alone and in combination with methicillin, cefamandole, gentamicin, trimethoprim, and vancomycin. Fosfomycin inhibited 90% of the 148 methicillin-resistant S. aureus strains at a concentration of 4 micrograms/ml. Synergism was observed in 97 strains (66%) with fosfomycin-cefamandole and in 69 strains (46%) with fosfomycin-methicillin. The combinations of fosfomycin with vancomycin, gentamicin, and trimethoprim were indifferent in most strains.
摘要
我们测试了148株耐甲氧西林金黄色葡萄球菌临床分离株对单独使用磷霉素以及与甲氧西林、头孢孟多、庆大霉素、甲氧苄啶和万古霉素联合使用时的效果。磷霉素在浓度为4微克/毫升时可抑制148株耐甲氧西林金黄色葡萄球菌菌株中的90%。在97株（66%）磷霉素-头孢孟多组合和69株（46%）磷霉素-甲氧西林组合中观察到协同作用。磷霉素与万古霉素、庆大霉素和甲氧苄啶的组合在大多数菌株中无协同作用。
相似文献
1
In vitro activity of fosfomycin, alone and in combination, against methicillin-resistant Staphylococcus aureus.磷霉素单独及联合使用时对耐甲氧西林金黄色葡萄球菌的体外活性。
Antimicrob Agents Chemother. 1985 Nov;28(5):689-90. doi: 10.1128/AAC.28.5.689.
2
3
In vitro activity of fosfomycin against methicillin-susceptible and methicillin-resistant Staphylococcus aureus.磷霉素对甲氧西林敏感及耐甲氧西林金黄色葡萄球菌的体外活性
Infection. 1984 Jul-Aug;12(4):293-5. doi: 10.1007/BF01645964.
4
In vitro and in vivo study of fosfomycin in methicillin-resistant Staphylococcus aureus septicaemia.磷霉素治疗耐甲氧西林金黄色葡萄球菌败血症的体内外研究
J Hyg (Lond). 1986 Jun;96(3):419-23. doi: 10.1017/s0022172400066183.
5
Gentamicin- and methicillin-resistant, clinical isolates of Staphylococcus aureus: comparative in vitro and in vivo efficacy of alternative antimicrobial drugs.庆大霉素和甲氧西林耐药的金黄色葡萄球菌临床分离株：替代抗菌药物的体外和体内疗效比较
Chemotherapy. 1984;30(2):102-12. doi: 10.1159/000238255.
6
Effects of antibiotic combinations on methicillin-resistant Staphylococcus aureus in vitro.抗生素联合用药对耐甲氧西林金黄色葡萄球菌的体外作用
Taiwan Yi Xue Hui Za Zhi. 1989 May;88(5):488-92.
7
Antibacterial activity of cefmetazole alone and in combination with fosfomycin against methicillin- and cephem-resistant Staphylococcus aureus.头孢美唑单独及与磷霉素联合对耐甲氧西林和耐头孢菌素金黄色葡萄球菌的抗菌活性
Antimicrob Agents Chemother. 1986 Dec;30(6):917-22. doi: 10.1128/AAC.30.6.917.
8
[In vitro study of the cefamandole-fosfomycin combination against methicillin-resistant staphylococci].头孢孟多-磷霉素联合用药对耐甲氧西林葡萄球菌的体外研究
Pathol Biol (Paris). 1984 Jun;32(5 Pt 2):528-31.
9
In vitro activities of teichomycin, fusidic acid, flucloxacillin, fosfomycin, and vancomycin against methicillin-resistant Staphylococcus aureus.替考拉宁、夫西地酸、氟氯西林、磷霉素和万古霉素对耐甲氧西林金黄色葡萄球菌的体外活性。
Antimicrob Agents Chemother. 1984 Aug;26(2):268-9. doi: 10.1128/AAC.26.2.268.
引用本文的文献
1
Synergistic activity of fosfomycin and flucloxacillin against methicillin-susceptible and methicillin-resistant Staphylococcus aureus: in vitro and in vivo assessment.磷霉素与氟氯西林对甲氧西林敏感及耐药金黄色葡萄球菌的协同活性：体内外评估
Med Microbiol Immunol. 2025 Jun 21;214(1):32. doi: 10.1007/s00430-025-00841-3.
2
Fosfomycin as Partner Drug for Systemic Infection Management. A Systematic Review of Its Synergistic Properties from In Vitro and In Vivo Studies.磷霉素作为全身感染管理的联合用药。对其体外和体内研究协同特性的系统评价。
Antibiotics (Basel). 2020 Aug 10;9(8):500. doi: 10.3390/antibiotics9080500.
3
Current perspectives on diagnosis and management of sternal wound infections.胸骨伤口感染的诊断与管理现状
Infect Drug Resist. 2018 Jul 16;11:961-968. doi: 10.2147/IDR.S130172. eCollection 2018.
4
A randomized double-blind placebo-controlled dose-escalation phase 1 study of aerosolized amikacin and fosfomycin delivered via the PARI investigational eFlow® inline nebulizer system in mechanically ventilated patients.一项在机械通气患者中进行的随机双盲安慰剂对照剂量递增1期研究，通过PARI investigational eFlow®在线雾化器系统给予雾化阿米卡星和磷霉素。
J Aerosol Med Pulm Drug Deliv. 2014 Dec;27(6):441-8. doi: 10.1089/jamp.2013.1100.
5
Aerosolized antibiotics: do they add to the treatment of pneumonia?雾化抗生素：它们能治疗肺炎吗？
Curr Opin Infect Dis. 2013 Dec;26(6):538-44. doi: 10.1097/QCO.0000000000000004.
6
Synergy of fosfomycin with other antibiotics for Gram-positive and Gram-negative bacteria.磷霉素与其他抗生素对革兰氏阳性菌和革兰氏阴性菌的协同作用。
Eur J Clin Pharmacol. 2010 Apr;66(4):359-68. doi: 10.1007/s00228-010-0794-5. Epub 2010 Feb 26.
7
Fosfomycin: an old, new friend?磷霉素：故友还是新朋？
Eur J Clin Microbiol Infect Dis. 2010 Feb;29(2):127-42. doi: 10.1007/s10096-009-0833-2. Epub 2009 Nov 14.
8
Nosocomial septicemias due to methicillin-resistant staphylococcus aureus and Pseudomonas aeruginosa in a university hospital over a 12-year period--the same intractable infections.一所大学医院12年间耐甲氧西林金黄色葡萄球菌和铜绿假单胞菌所致的医院败血症——同样棘手的感染。
Infection. 1996 May-Jun;24(3):238-41. doi: 10.1007/BF01781100.
9
In vitro interactions between different beta-lactam antibiotics and fosfomycin against bloodstream isolates of enterococci.不同β-内酰胺类抗生素与磷霉素对肠球菌血流分离株的体外相互作用
Antimicrob Agents Chemother. 1995 Oct;39(10):2341-4. doi: 10.1128/AAC.39.10.2341.
10
Single- and combination-antibiotic therapy for experimental endocarditis caused by methicillin-resistant Staphylococcus aureus.针对耐甲氧西林金黄色葡萄球菌引起的实验性心内膜炎的单一抗生素疗法和联合抗生素疗法
Antimicrob Agents Chemother. 1987 Sep;31(9):1444-5. doi: 10.1128/AAC.31.9.1444.
本文引用的文献
1
International recognition of methicillin-resistant strains of Staphylococcus aureus.
Ann Intern Med. 1982 Dec;97(6):925-6. doi: 10.7326/0003-4819-97-6-925.
2
Vancomycin therapy for methicillin-resistant Staphylococcus aureus.针对耐甲氧西林金黄色葡萄球菌的万古霉素治疗
Ann Intern Med. 1982 Sep;97(3):344-50. doi: 10.7326/0003-4819-97-3-344.
3
Epidemiology of nosocomial infections caused by methicillin-resistant Staphylococcus aureus.耐甲氧西林金黄色葡萄球菌引起的医院感染流行病学
Ann Intern Med. 1982 Sep;97(3):309-17. doi: 10.7326/0003-4819-97-3-309.
4
Methicillin-resistant Staphylococcus aureus: microbiologic characteristics, antimicrobial susceptibilities, and assessment of virulence of an epidemic strain.耐甲氧西林金黄色葡萄球菌：一种流行菌株的微生物学特征、抗菌药敏性及毒力评估
J Infect Dis. 1981 Dec;144(6):575-82. doi: 10.1093/infdis/144.6.575.
5
[Comparison of activity of fosfomycin, oxacillin and penicillin G against staphylococci and micrococci (author's transl)].磷霉素、苯唑西林和青霉素G对葡萄球菌及微球菌活性的比较（作者译）
Dtsch Med Wochenschr. 1980 Oct 31;105(44):1541-3. doi: 10.1055/s-2008-1070908.
6
Antimicrobial activity of fosfomycin in vitro.磷霉素的体外抗菌活性。
J Antimicrob Chemother. 1983 May;11(5):467-71. doi: 10.1093/jac/11.5.467.
7
Fosfomycin penetration into the cerebrospinal fluid of patients with bacterial meningitis.
Chemotherapy. 1981;27(6):405-13. doi: 10.1159/000238009.
8
Successful use of broth microdilution in susceptibility tests for methicillin-resistant (heteroresistant) staphylococci.肉汤微量稀释法在耐甲氧西林（异质性耐药）葡萄球菌药敏试验中的成功应用。
J Clin Microbiol. 1983 Nov;18(5):1084-91. doi: 10.1128/jcm.18.5.1084-1091.1983.
9
International collaborative study on standardization of bacterial sensitivity to fosfomycin.
J Antimicrob Chemother. 1983 Oct;12(4):357-61. doi: 10.1093/jac/12.4.357.
10
Vancomycin treatment of bacteremia caused by oxacillin-resistant Staphylococcus aureus: comparison with beta-lactam antibiotic treatment of bacteremia caused by oxacillin-sensitive Staphylococcus aureus.
J Infect Dis. 1983 Jan;147(1):137-43. doi: 10.1093/infdis/147.1.137.
Zotero 插件