Stephens J, Hayward R, Ead H, Adams L, Hamer J, Spurrell R
Br Heart J. 1978 Aug;40(8):856-63. doi: 10.1136/hrt.40.8.856.
The effects on coronary dynamics of propranolol and atenolol were studied in 12 patients undergoing cardiac catheterisation for suspected coronary artery disease. Myocardial blood flow was measured using the coronary sinus continuous thermodilution technique. Data were obtained immediately after drug administration and during rapid atrial pacing. The immediate effects were similar for both drugs. A significant reduction in heart rate was accompanied by a small reduction in myocardial oxygen consumption. Changes in coronary sinus flow induced by rapid pacing were closely related to changes in tension-time index. This relation was not modified by propranolol or atenolol. Neither propranolol nor atenolol therefore has significant coronary vasoconstrictor properties. Cardioselectivity appears to be unimportant with respect to beta-adrenergic blockade and the coronary circulation.
对12例因疑似冠状动脉疾病而接受心导管检查的患者，研究了普萘洛尔和阿替洛尔对冠状动脉动力学的影响。采用冠状窦连续热稀释技术测量心肌血流量。在给药后即刻以及快速心房起搏期间获取数据。两种药物的即刻效应相似。心率显著降低，同时心肌耗氧量略有减少。快速起搏引起的冠状窦血流变化与张力-时间指数变化密切相关。普萘洛尔或阿替洛尔未改变这种关系。因此，普萘洛尔和阿替洛尔均无明显的冠状动脉血管收缩特性。就β-肾上腺素能阻滞和冠状动脉循环而言，心脏选择性似乎并不重要。
