吲哚洛尔对冠心病患者静息及起搏时心肌血流、代谢及功能的影响。
The effect of pindolol on myocardial blood flow, metabolism and function during rest and pacing in patients with coronary heart disease.
作者信息
Kupper W, Hamm C W, Bleifeld W
出版信息
Br J Clin Pharmacol. 1982;13(Suppl 2):309S-312S. doi: 10.1111/j.1365-2125.1982.tb01932.x.
Abstract
1 The study was designed to elucidate further the mechanism by which beta-adrenoceptor antagonism with pindolol relieves the symptoms of angina pectoris in patients with coronary heart disease. 2 Pindolol administration was associated with an elevated threshold for angina pectoris and improved myocardial lactate metabolism during supraventricular pacing. 3 This beneficial effect of pindolol was independent of changes in myocardial blood flow and was not mediated by haemodynamic effects. 4 The results suggest that in angina pectoris, in addition to the recognized beneficial effects of beta-adrenoceptor blockade, the actions of pindolol also result from, as yet, poorly described phenomena such as redistribution of myocardial blood flow or metabolic effects.
摘要
- 本研究旨在进一步阐明吲哚洛尔拮抗β-肾上腺素能受体缓解冠心病患者心绞痛症状的机制。2. 服用吲哚洛尔与心绞痛阈值升高及室上性起搏期间心肌乳酸代谢改善有关。3. 吲哚洛尔的这种有益作用与心肌血流量的变化无关，也不是由血流动力学效应介导的。4. 结果表明，在心绞痛中，除了β-肾上腺素能受体阻滞剂公认的有益作用外，吲哚洛尔的作用还源于心肌血流重新分布或代谢效应等尚未充分描述的现象。
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