Jean A, Amri M, Calas A
J Auton Nerv Syst. 1983 Feb;7(2):87-96. doi: 10.1016/0165-1838(83)90038-3.
The anatomical connections between two regions involved in swallowing, the medullary reticular formation around the nucleus ambiguous (ventral group of swallowing interneurons) and the trigeminal motor nucleus (NMV) were studied in sheep using anterograde and retrograde tracing techniques. [3H]leucine and HRP were injected into the ventral medulla and the NMV respectively. These injections were performed according to stereotaxic coordinates previously established by electrophysiological recording tests. The results show bilateral connections between the ventral medulla, 2-4 mm rostral to the obex, and the trigeminal motor nucleus. In addition, the same area of the ventral medulla is connected with the homologous contralateral region and with the facial, vagal and hypoglossal nuclei that are also involved in swallowing. Some connections between the ventral medulla and the NMV must be monosynaptic since aggregates of silver grains typical of axon terminals were observed on the cell bodies of trigeminal motoneurons. Obviously, the various connections shown to exist in this study may serve other functions than swallowing. Nevertheless, most of the results are consistent with the view that the ventral group of medullary swallowing interneurons are switching neurons that distribute the programmed swallowing excitation to the various motoneuron pools involved in deglutition.
运用顺行和逆行追踪技术，在绵羊身上研究了吞咽相关的两个区域——疑核周围的延髓网状结构（吞咽中间神经元腹侧组）和三叉神经运动核（NMV）之间的解剖学联系。分别将[³H]亮氨酸和辣根过氧化物酶注入延髓腹侧和NMV。这些注射是根据先前通过电生理记录测试确定的立体定位坐标进行的。结果显示，在延髓腹侧（闩前方2 - 4毫米处）与三叉神经运动核之间存在双侧联系。此外，延髓腹侧的同一区域与对侧同源区域以及同样参与吞咽的面神经核、迷走神经核和舌下神经核相连。延髓腹侧与NMV之间的一些联系必定是单突触的，因为在三叉神经运动神经元的胞体上观察到了典型的轴突终末银粒聚集体。显然，本研究中显示存在的各种联系可能具有除吞咽之外的其他功能。然而，大多数结果与以下观点一致，即延髓吞咽中间神经元腹侧组是转换神经元，它们将程序化的吞咽兴奋分配到参与吞咽的各种运动神经元池。
