Shih C J, Wu J J, Lin M T
J Auton Nerv Syst. 1983 May;8(1):33-43. doi: 10.1016/0165-1838(83)90021-8.
The autonomic (including sudomotor, baroreceptor, and vasomotor) functions were assessed in 3 groups of individuals, comprising normal, hyperhidrotic, and denervated subjects. The normal group had no palmar hyperhidrosis, with intact T2-3 ganglia, the hyperhidrotic group had palmar hyperhidrosis with intact T2-3 ganglia, and the denervated group had palmar hyperhidrosis treated with T2-3 ganglionectomy. Compared with both the normal and hyperhidrotic subjects, the denervated subjects had a much smaller sweating response of both the forehead, the upper chest region and the upper extremities, and a much greater sweating response of both the lateral lumbar and ventral thigh regions in response to body exercise. In addition, cardiovascular responses to either the Valsalva manoeuver, face immersion, or finger immersion were evaluated in these groups of subjects. When compared with those of either the normal or the denervated subjects, the hyperhidrotic subjects had less reflex bradycardia in response to either Valsalva manoeuver or face immersion. In contrast, when compared with those of either the normal or the denervated subjects, the hyperhidrotic subjects had a higher degree of cutaneous vasoconstriction in response to finger (or cold) immersion. The data indicate that the sympathetic fibers passing through the T2-3 ganglia play an important role in the elaboration or modulation of autonomic function elsewhere. Probably, the hyperhidrotic subjects have an over-functioning of the sympathetic nervous fibers which pass through the T2-3 ganglia, which leads to autonomic dysfunction. The autonomic dysfunctions observed in the hyperhidrotic subjects could be eliminated after the interruption of the excessive sympathetic activities passing through the T2-3 ganglia level. A preliminary report of this work was delivered at the 15th Congress of the Pan-Pacific Surgical Association, January 12-18, 1980 and the 12th World Congress of Neurology, September 20-25, 1981.
对三组个体的自主神经功能（包括汗腺运动功能、压力感受器功能和血管运动功能）进行了评估，这三组个体分别为正常受试者、多汗症患者和去神经支配受试者。正常组无手掌多汗症，T2 - 3神经节完整；多汗症组有手掌多汗症，T2 - 3神经节完整；去神经支配组曾接受T2 - 3神经节切除术治疗手掌多汗症。与正常受试者和多汗症患者相比，去神经支配受试者在身体运动时，前额、上胸部区域和上肢的出汗反应要小得多，但腰部外侧和大腿前侧区域的出汗反应要大得多。此外，还评估了这些受试者对瓦尔萨尔瓦动作、面部浸入或手指浸入的心血管反应。与正常受试者或去神经支配受试者相比，多汗症患者在瓦尔萨尔瓦动作或面部浸入时的反射性心动过缓较少。相反，与正常受试者或去神经支配受试者相比，多汗症患者在手指（或冷）浸入时的皮肤血管收缩程度更高。数据表明，通过T2 - 3神经节的交感神经纤维在其他部位自主神经功能的形成或调节中起重要作用。多汗症患者可能存在通过T2 - 3神经节的交感神经纤维功能亢进，这导致了自主神经功能障碍。多汗症患者中观察到的自主神经功能障碍在阻断通过T2 - 3神经节水平的过度交感神经活动后可以消除。这项工作的初步报告于1980年1月12 - 18日在泛太平洋外科协会第15届大会以及1981年9月20 - 25日在第12届世界神经学大会上发表。
