Béchetoille A, Allain P, Ebran J M, Mauras Y
J Fr Ophtalmol. 1983;6(3):231-5.
Plasma red blood cell and total blood zinc levels were significantly decreased in 52 consecutives cases of bilateral, retrobulbar, axial optic neuropathy caused by chronic abuse of ordinary wine and/or beer and/or hard beverages and cigarette smoking principally in men in their forties [plasma zinc: 746 mg/l +/- 179 (n = 52), control 907 mg/l +/- 127; red blood cell zinc: 10,218 mg/l +/- 1,327 (n = 10), control 12,244 mg/l +/- 1,307; total blood zinc: 4,849 mg/l +/- 1,069 (n = 51), control 5,831 mg/l +/- 644]. In contrast, blood lead levels were increased in these cases - blood lead: 344 mg/l +/- 101 (n = 30), control 193 mg/l +/- 94. Activity of red blood cell delta-amino-levulinic acid dehydratase (ALA-dehydratase), a zinc dependent enzyme, was decreased [red blood cell ALA-dehydratase; 18,8 IU/l +/- 2,2 (n = 13), control 44,8 IU/l +/- 3,3]. Plasma magnesium was slightly decreased while serum copper was not significantly modified. Possible ophthalmological implication of these findings are discussed.
在52例主要为40多岁男性因长期滥用普通葡萄酒和/或啤酒和/或烈性饮料及吸烟导致的双侧、球后、轴索性视神经病变的连续病例中，血浆红细胞和全血锌水平显著降低[血浆锌：746mg/L±179（n=52），对照组907mg/L±127；红细胞锌：10218mg/L±1327（n=10），对照组12244mg/L±1307；全血锌：4849mg/L±1069（n=51），对照组5831mg/L±644]。相比之下，这些病例的血铅水平升高——血铅：344mg/L±101（n=30），对照组193mg/L±94。红细胞δ-氨基-γ-酮戊酸脱水酶（ALA-脱水酶）（一种锌依赖酶）的活性降低[红细胞ALA-脱水酶；18.8IU/L±2.2（n=13），对照组44.8IU/L±3.3]。血浆镁略有降低，而血清铜无显著变化。讨论了这些发现可能的眼科意义。
