Gorwill R H, Sarda I R
Br J Obstet Gynaecol. 1978 Aug;85(8):602-4. doi: 10.1111/j.1471-0528.1978.tb14928.x.
To examine the effect on oestrogen metabolism of the stimulus which causes the passage of meconium, we measured maternal venous and cord artery and vein serum unconjugated oestriol levels in 46 patients with meconium staining of the amniotic fluid and 19 controls. Mean cord vein oestriol levels were significantly lower than in controls in the presence of meconium stained amniotic fluid and no fetal acidosis (cord artery buffer base of 36.2 meq/l or more) (P less than 0.02). The same tendency was seen with acidotic infants (P less than 0.05). There is thus evidence of a change in oestrogen metabolism associated with meconium staining of the amniotic fluid.
为研究引起胎粪排出的刺激对雌激素代谢的影响，我们测定了46例羊水胎粪污染患者及19例对照者的母血静脉血、脐动脉血和脐静脉血中未结合雌三醇水平。在羊水胎粪污染且无胎儿酸中毒（脐动脉缓冲碱为36.2meq/l或更高）的情况下，脐静脉雌三醇平均水平显著低于对照组（P<0.02）。酸中毒婴儿也有同样的趋势（P<0.05）。因此，有证据表明羊水胎粪污染与雌激素代谢变化有关。
