Rodriguez-Soriano J, Vallo A, Castillo G, Oliveros R, Cea J M, Balzategui M J
J Pediatr. 1983 Aug;103(2):209-14. doi: 10.1016/s0022-3476(83)80346-1.
The diagnosis in one infant of a severe state of chloride deficiency after ingesting a diet consisting exclusively of a modified cow milk formula containing only 0.5 mEq/100 kcal chloride ion led to the identification of 30 additional infants (age 2.6 +/- 0.7 months) fed the same commercial formula. The total absence of chloride in the urine was used as a biochemical index of subclinical dietary chloride deficiency. Serum and urine values were studied at diagnosis and 10 to 12 days after chloride replenishment, and compared statistically with the values obtained in a control group of 40 infants (age 2.8 +/- 1.2 months) fed exclusively a different modified formula containing an adequate chloride concentration. The outstanding laboratory abnormalities noted in the infants ingesting a low chloride formula were hypochloremia and metabolic alkalosis. Mean serum concentrations of potassium, urea, creatinine, and uric acid were in the normal range, but group values were statistically different from normal. A previously unreported finding was the demonstration of a significant elevation in the serum concentrations of calcium and phosphate and in the urinary excretions of calcium and magnesium, which persisted after almost complete recovery of the remaining biochemical disturbances. These results indicate the potential risk of nephrocalcinosis after dietary chloride deficiency.
一名婴儿在摄入仅含0.5毫当量/100千卡氯离子的改良牛奶配方奶组成的单一饮食后，被诊断为严重氯缺乏状态，这促使人们识别出另外30名（年龄2.6±0.7个月）喂养相同商业配方奶的婴儿。尿中完全无氯被用作亚临床饮食性氯缺乏的生化指标。在诊断时以及补充氯后10至12天研究血清和尿液值，并与40名（年龄2.8±1.2个月）仅喂养含充足氯浓度的不同改良配方奶的对照组婴儿所获得的值进行统计学比较。摄入低氯配方奶的婴儿中显著的实验室异常为低氯血症和代谢性碱中毒。钾、尿素、肌酐和尿酸的平均血清浓度在正常范围内，但组值与正常情况有统计学差异。一个先前未报告的发现是血清钙和磷浓度以及尿钙和镁排泄量显著升高，在其余生化紊乱几乎完全恢复后这一现象仍持续存在。这些结果表明饮食性氯缺乏后发生肾钙质沉着症的潜在风险。
