氘标记的丙氯拉嗪的合成。
Synthesis of deuterium-labeled prochlorperazine.
作者信息
Hawes E M, Gurnsey T S, Shetty H U, Midha K K
出版信息
J Pharm Sci. 1983 Jun;72(6):702-3. doi: 10.1002/jps.2600720628.
PMID:6875835
Abstract
The propylpiperazine side chain of prochlorperazine was labeled with two, four, or six deuterium atoms by lithium aluminum deuteride reduction of the appropriate amide. The isotopic purity of the products after correcting for chlorine isotopes was greater than 95.7%.
摘要
通过用氘化铝锂还原相应的酰胺，将丙氯拉嗪的丙基哌嗪侧链标记上两个、四个或六个氘原子。校正氯同位素后，产物的同位素纯度大于95.7%。
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