van Zoelen E J, Blok M C, Stafleu G P, Lancée-Hermkens A M, Henriques de Jesus C, De Gier J
Biochim Biophys Acta. 1978 Aug 17;511(3):320-34. doi: 10.1016/0005-2736(78)90270-5.
The non-electrolyte permeability of liposomal membranes has been investigated according to the concepts of irreversible thermodynamics. A strong interaction between the permeation of solute and water was observed. This solute-solvent interaction can be fully described by assuming that a number of water molecules will copermeate with each molecule of solute. This number of copermeating water molecules is independent of the nature of the permeant and of temperature, but depends on the osmotic concentration of impermeants inside the liposomes.
根据不可逆热力学的概念，对脂质体膜的非电解质渗透性进行了研究。观察到溶质渗透与水之间存在强烈的相互作用。这种溶质 - 溶剂相互作用可以通过假设每个溶质分子会有一定数量的水分子共同渗透来充分描述。共同渗透的水分子数量与渗透物的性质和温度无关，但取决于脂质体内非渗透物的渗透浓度。
