Clayman R V, Ortlip S A, Eckfeldt J H
J Urol. 1983 Aug;130(2):279-82. doi: 10.1016/s0022-5347(17)51107-6.
It has been suggested recently that increases in the concentration of the MB isoenzyme of creatine kinase after transurethral operations could result from release of creatine kinase-MB by prostatic or bladder tissues and, therefore, that creatine kinase-MB is not specific for myocardial damage. Our study of 53 patients undergoing transurethral operations and 37 undergoing urethral dilations showed that creatine kinase-MB is not released in significant quantities from the prostate or bladder. Therefore, we believe that an elevated creatine kinase-MB concentration is specific for myocardial infarction in these patients. We also concluded that the increase in total serum creatine kinase activity in these patients probably results from release of the creatine kinase-MM isoenzyme from periurethral muscle damage by electrocautery.
最近有人提出，经尿道手术后肌酸激酶MB同工酶浓度的升高可能是由于前列腺或膀胱组织释放肌酸激酶-MB所致，因此，肌酸激酶-MB并非心肌损伤的特异性指标。我们对53例行经尿道手术的患者和37例行尿道扩张术的患者进行的研究表明，前列腺或膀胱不会大量释放肌酸激酶-MB。因此，我们认为，肌酸激酶-MB浓度升高对这些患者的心肌梗死具有特异性。我们还得出结论，这些患者血清总肌酸激酶活性的升高可能是由于电灼造成尿道周围肌肉损伤，从而释放出肌酸激酶-MM同工酶所致。
