Du J, Yang Z
Hua Xi Yi Ke Da Xue Xue Bao. 1992 Jun;23(2):178-80.
Intravenous drip of sodium pentobarbital 6 mg/kg per min induced obvious heart failure of anesthetic dogs (n = 11) followed by an infusion of 0.25 mg/kg per min to maintain the heart failure state. The Chinese-made vesnarinone 3 mg/kg was injected, followed by an infusion of 0.1 mg/kg per min, or the solvent in the same volume, for 30 min. Vesnarinone increased significantly and instantly the cardiac output and left ventricular maximum + dp/dt, which almost recovered to normal at the end of the infusion and also significantly increased 30 min after administration. The positive inotropic effect of vesnarinone was not accompanied by an increase in the heart rate and the blood pressure. The results of our experiment reveal that the Chinese-made vesnarinone has a potent and relatively selective positive action on heart failure of dogs.
以每分钟6毫克/千克的速度静脉滴注戊巴比妥钠可使11只麻醉犬出现明显的心衰，随后以每分钟0.25毫克/千克的速度输注以维持心衰状态。静脉注射国产维司力农3毫克/千克，随后以每分钟0.1毫克/千克的速度输注，或输注相同体积的溶剂，持续30分钟。维司力农能迅速且显著增加心输出量和左心室最大dp/dt，输注结束时几乎恢复正常，给药后30分钟也显著增加。维司力农的正性肌力作用未伴有心率和血压升高。我们的实验结果表明，国产维司力农对犬心衰有强效且相对选择性的正性作用。
