Chawla A S
Biomater Med Devices Artif Organs. 1978;6(2):89-102. doi: 10.3109/10731197809118695.
To evaluate the thrombogenicity of the novel filler free silicone rubber (FFSR) prepared in our laboratory, its interactions with blood were studied. The test samples (FFSR) along with control Silastic samples were placed in an extracorporeal shunt and primed with sterilized normal saline. The blood from an anaesthetized and systemically heparinized dog was passed over these samples for predetermined time intervals. After washing, fixing, etc., the platelets adhering to the samples were counted under light microscopy. To study the morphological changes of the platelets adhering to the samples, they were examined under scanning electron microscope. The number of platelets adhering to the FFSR samples was very small compared to the Silastic samples. For example, when the blood was passed over the samples for 10 min the number of platelets sticking per 0.14 mm2 surface area was 10 for FFSR samples compared to 380 for Silastic. Furthermore, there were no leukocytes on FFSR samples compared to 10 on Silastic. From these studies, the novel filler free silicone rubber prepared in our laboratory was judged to be more compatible with formed elements of blood compared to the Silastic material.
为评估我们实验室制备的新型无填料硅橡胶（FFSR）的血栓形成性，对其与血液的相互作用进行了研究。将测试样品（FFSR）以及对照硅橡胶样品置于体外分流器中，并用灭菌生理盐水灌注。将来自麻醉且全身肝素化犬的血液在预定时间间隔内流经这些样品。经过洗涤、固定等处理后，在光学显微镜下对粘附在样品上的血小板进行计数。为研究粘附在样品上的血小板的形态变化，在扫描电子显微镜下对其进行检查。与硅橡胶样品相比，粘附在FFSR样品上的血小板数量非常少。例如，当血液流经样品10分钟时，每0.14平方毫米表面积上粘附的血小板数量，FFSR样品为10个，而硅橡胶样品为380个。此外，FFSR样品上没有白细胞，而硅橡胶样品上有10个。从这些研究中可以判断，我们实验室制备的新型无填料硅橡胶与硅橡胶材料相比，与血液中的有形成分更具相容性。
