Kitz D J, Embree R W, Cazin J
Mycopathologia. 1983 Apr 22;82(1):17-22. doi: 10.1007/BF00436940.
The comparative virulence of thermotolerant Mucorales was determined for cortisone-treated and untreated Swiss mice by intravenous administration of spores. The measure of virulence was based on an LD50 value, calculated after the 30-day observation period. Of the known etiological agents of mucormycosis, Mucor meihei, M. pusillus, Rhizopus arrhizus, R. chinensis, R. cohnii, R. microsporus, R. oryzae, R. rhizopodiformis and Cunninghamella elegans were able to produce fatal infections in mice; whereas, Mucor alternans, M. ramosissimus and Syncephalastrum racemosum were avirulent at dosages of up to 10(5) spores. Of those thermotolerant species which have not been reported to cause mucormycosis in human beings, Radiomyces embreei, R. spectabilis, Rhizopus oligosporus and Thermomucor indicae-seudaticae were found to produce fatal infections in mice; whereas, an isolate of Mycotypha africana was avirulent. Cortisone treatment of mice was found to lower their resistance to infection at a given spore dosage as measured by ET50 values.
通过静脉注射孢子，测定了耐热毛霉目真菌对经可的松处理和未经处理的瑞士小鼠的相对毒力。毒力的衡量基于30天观察期后计算得出的半数致死剂量（LD50）值。在已知的毛霉病病原体中，米黑根毛霉、微小毛霉、少根根霉、华根霉、科氏根霉、小孢根霉、米根霉、类根状根霉和雅致小克银汉霉能够在小鼠中引发致命感染；而交链毛霉、多枝毛霉和总状共头霉在高达10⁵个孢子的剂量下无致病性。在那些尚未报道可在人类中引起毛霉病的耐热菌种中，恩氏放射菌、壮观放射菌、少孢根霉和印度嗜热毛霉被发现可在小鼠中引发致命感染；而非洲被孢霉的一个分离株无致病性。通过ET50值测定发现，对小鼠进行可的松处理会降低其在给定孢子剂量下对感染的抵抗力。
