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豚鼠前胰高血糖素原基因的突变局限于激素原序列的特定部分。

Mutations in the guinea pig preproglucagon gene are restricted to a specific portion of the prohormone sequence.

作者信息

Seino S, Welsh M, Bell G I, Chan S J, Steiner D F

出版信息

FEBS Lett. 1986 Jul 14;203(1):25-30. doi: 10.1016/0014-5793(86)81429-6.

DOI:10.1016/0014-5793(86)81429-6
PMID:3755107
Abstract

A cDNA clone encoding guinea pig preproglucagon has been isolated from a pancreatic cDNA library. The predicted amino acid sequence of proglucagon is highly conserved in all regions, in comparison to other mammals, except for the C-terminal portion of the 29-residue glucagon region, in which 5 amino acid substitutions have occurred. These changes may serve to offset the reduced receptor-binding potency of the highly mutated insulin in this New World species.

摘要

从豚鼠胰腺cDNA文库中分离出一个编码前胰高血糖素原的cDNA克隆。与其他哺乳动物相比，胰高血糖素原的预测氨基酸序列在所有区域都高度保守，除了29个氨基酸残基的胰高血糖素区域的C端部分，该区域发生了5个氨基酸的替换。这些变化可能有助于抵消这种新大陆物种中高度突变的胰岛素降低的受体结合能力。

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Mutations in the guinea pig preproglucagon gene are restricted to a specific portion of the prohormone sequence.豚鼠前胰高血糖素原基因的突变局限于激素原序列的特定部分。
FEBS Lett. 1986 Jul 14;203(1):25-30. doi: 10.1016/0014-5793(86)81429-6.
2
Cloning of complementary DNAs encoding islet amyloid polypeptide, insulin, and glucagon precursors from a New World rodent, the degu, Octodon degus.从一种新大陆啮齿动物八齿鼠（Octodon degus）中克隆编码胰岛淀粉样多肽、胰岛素和胰高血糖素前体的互补DNA。
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Hamster preproglucagon contains the sequence of glucagon and two related peptides.仓鼠前胰高血糖素原包含胰高血糖素的序列以及两种相关肽。
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Identification of a proglucagon cDNA from Rana tigrina rugulosa that encodes two GLP-1s and that is alternatively spliced in a tissue-specific manner.从虎纹蛙中鉴定出一种胰高血糖素原cDNA，其编码两种胰高血糖素样肽-1（GLP-1），并以组织特异性方式进行可变剪接。
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Exon duplication and divergence in the human preproglucagon gene.人类前胰高血糖素原基因中的外显子重复与分化。
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Sequence and evolution of guinea pig preproinsulin DNA.豚鼠胰岛素原前体DNA的序列与进化
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