Duncan I D
Neuropathol Appl Neurobiol. 1983 May-Jun;9(3):195-206. doi: 10.1111/j.1365-2990.1983.tb00107.x.
The biceps femoris muscle was cut close to its distal tendon in seventeen rats, inserted under the partially freed sciatic nerve and the muscle then resutured leaving the nerve in a translocated position. The rats were killed at intervals from 4 to 22 weeks later and the sciatic nerve above, around, and below the muscle reflection site examined by light and electron microscopy and teased fibre preparations. In all cases, the sciatic nerve was affected to varying degrees at its reflected site ranging from focal sub-perineurial demyelination and remyelination to widespread myelin sheath abnormalities. Teased fibre studies confirmed that the myelin sheath was predominantly affected with little evidence of active axonal degeneration. There was no proximal and minimal distal sciatic nerve damage. The most likely cause of these changes was thought to be focal compression but the possible role of other factors is also discussed.
在17只大鼠中，股二头肌在靠近其远端肌腱处被切断，将其插入部分游离的坐骨神经下方，然后将肌肉重新缝合，使神经处于移位位置。在4至22周后的不同时间点处死大鼠，通过光镜、电镜以及 teased纤维制备对肌肉反射部位上方、周围和下方的坐骨神经进行检查。在所有病例中，坐骨神经在其反射部位均受到不同程度的影响，范围从局灶性神经束膜下脱髓鞘和再髓鞘化到广泛的髓鞘异常。teased纤维研究证实，髓鞘受到的影响最为显著，几乎没有活跃轴突变性的证据。坐骨神经近端没有损伤，远端损伤也很轻微。这些变化最可能的原因被认为是局灶性压迫，但也讨论了其他因素可能发挥的作用。
