Drescher C W, Peters W A, Roberts J A
Obstet Gynecol. 1983 Sep;62(3):343-7. doi: 10.1097/00006250-198309000-00016.
A review of 540 patients evaluated by the Gynecologic Colposcopy Clinic for abnormal cervical cytology revealed that 372 (68.9%) had cervical intraepithelial neoplasia (CIN), microinvasive carcinoma, or frank invasive carcinoma. The repeat cytologic smear taken before biopsy was falsely negative in 26.4%. An endocervical curettage was obtained in 52.5% of patients with an adequate colposcopy who had a neo-plastic lesion and was positive in 17.9% of those sampled, including six patients with no lesion found on the ectocervix. An endocervical curettage was obtained in 88.5% of patients with an inadequate colposcopy who had a neoplastic lesion, and was positive in 48.7%. All patients with an inadequate colposcopy not having an endocervical curettage underwent conization of the cervix. Twelve patients (2.2%) were ultimately found to have invasive or microinvasive carcinoma. A positive endocervical curettage and an inadequate colposcopy were both correlated with a final diagnosis of invasion. The contribution of endocervical curettage to the outpatient work-up of abnormal cervical cytology is substantial and it should be performed in all patients in whom cone biopsy is not planned.
对妇科阴道镜诊所评估的540例宫颈细胞学异常患者的回顾显示，372例（68.9%）患有宫颈上皮内瘤变（CIN）、微浸润癌或浸润性癌。活检前进行的重复细胞学涂片假阴性率为26.4%。在52.5%阴道镜检查充分且有肿瘤性病变的患者中进行了宫颈管刮除术，其中17.9%的取样患者结果为阳性，包括6例宫颈外口未发现病变的患者。在88.5%阴道镜检查不充分且有肿瘤性病变的患者中进行了宫颈管刮除术，阳性率为48.7%。所有阴道镜检查不充分且未进行宫颈管刮除术的患者均接受了宫颈锥形切除术。最终发现12例患者（2.2%）患有浸润性癌或微浸润癌。宫颈管刮除术结果阳性和阴道镜检查不充分均与最终的浸润性诊断相关。宫颈管刮除术对宫颈细胞学异常门诊检查的贡献很大，应在所有不计划进行锥形活检的患者中进行。
