Förster H J, Stähle H
Biomed Mass Spectrom. 1978 Aug;5(8):483-7. doi: 10.1002/bms.1200050804.
The structures of the methylated clonidine derivatives formed by on column methylation with trimethylanilinium hydroxide are revised. The almost exclusive formation of derivatives of phenylimino-N,N-dimethylimidazolidine structure is explained in terms of a fast kinetically controlled reaction of substrate anions. The reliability of a stable isotope dilution assay for clonidine is discussed in view of these results.
对通过用氢氧化三甲基苯胺进行柱上甲基化形成的甲基化可乐定衍生物的结构进行了修正。从底物阴离子的快速动力学控制反应角度解释了几乎唯一形成苯基亚氨基-N，N-二甲基咪唑烷结构衍生物的原因。鉴于这些结果，讨论了可乐定稳定同位素稀释分析的可靠性。
