Harrison R A, Doenhoff M J
Parasitology. 1983 Jun;86 (Pt 3):429-38. doi: 10.1017/s0031182000050629.
Previous observations, which showed that treatment of mice with hydrocortisone acetate around the time of their infection with Schistosoma mansoni reduced the mature worm burden, have been confirmed. The number of eggs produced by the surviving worms during early patency was also significantly reduced. Cyclophosphamide and another steroid immunosuppressant, betamethasone, also caused a reduction in fecundity of S. mansoni when given at the time of infection, as did T-cell deprivation of the mice by adult thymectomy and injection of anti-thymocyte serum 1 month before infection. There was no effect of these three treatments on worm numbers. In contrast, injection of mice with anti-thymocyte serum at the time of infection marginally increased the size of the mature worm burden. The deleterious effects of hydrocortisone acetate on S. mansoni worm numbers and fecundity were only apparent if the steroid was given within 1 week of infection. Indomethacin, a compound which inhibits tissue inflammatory reactions by inhibiting prostaglandin synthesis, and which therefore mimics one of the actions of corticosteroids, had no effect on S. mansoni worm maturation and fecundity.
先前的观察结果显示，在感染曼氏血吸虫前后用醋酸氢化可的松治疗小鼠可减少成熟虫体数量，这一结果已得到证实。在早期产卵期存活虫体产生的卵数量也显著减少。环磷酰胺和另一种类固醇免疫抑制剂倍他米松在感染时给药也会导致曼氏血吸虫繁殖力下降，成年小鼠胸腺切除并在感染前1个月注射抗胸腺细胞血清以剥夺其T细胞也有同样效果。这三种处理对虫体数量均无影响。相反，在感染时给小鼠注射抗胸腺细胞血清会使成熟虫体数量略有增加。醋酸氢化可的松对曼氏血吸虫虫体数量和繁殖力的有害作用只有在感染后1周内给予类固醇时才明显。吲哚美辛是一种通过抑制前列腺素合成来抑制组织炎症反应的化合物，因此模拟了皮质类固醇的一种作用，对曼氏血吸虫的虫体成熟和繁殖力没有影响。
