Moloney N A, Doenhoff M J, Webbe G, Hinchcliffe P
Parasite Immunol. 1982 Nov;4(6):431-40. doi: 10.1111/j.1365-3024.1982.tb00454.x.
Infections of Schistosoma japonicum were studied in mice which were immunosuppressed either by thymectomy and administration of antithymocyte serum or by treatment with hydrocortisone acetate. The relation of S. japonicum with the immunosuppressed host differed with that reported for Schistosoma mansoni. The pathogenesis of the S. japonicum infection in the immunosuppressed host was less severe than that caused by S. mansoni, with respect to survival of, and hepatocellular damage to, the host. In contrast with S. mansoni, S. japonicum did not have a reduced fecundity in immunosuppressed mice and there was no significant reduction in the numbers of faecal eggs excreted by these hosts.
在通过胸腺切除和给予抗胸腺细胞血清或用醋酸氢化可的松治疗而免疫抑制的小鼠中研究了日本血吸虫感染。日本血吸虫与免疫抑制宿主的关系与曼氏血吸虫的报道不同。就宿主的存活和肝细胞损伤而言，免疫抑制宿主中日本血吸虫感染的发病机制不如曼氏血吸虫所致的严重。与曼氏血吸虫相反，日本血吸虫在免疫抑制小鼠中的繁殖力没有降低，这些宿主排出的粪便虫卵数量也没有显著减少。
