Iarochkin V S, Koziner V B
Biull Eksp Biol Med. 1978 Aug;86(8):131-3.
Basic values of blood circulation and respiration were compared in two groups of cats. The blood of group I animals was replaced by a 8% solution of human Hb completely free of stroma and procoaglulant activity. In group II animals the blood was diluted with polyglucine to the Hb level of 8 g%. The solution is well saturated in the lungs and releases O2 to tissues, but much less than Hb contained in red cells. The dissolved Hb did not completely meet the requirements of the organism in oxygen with the resultant hypoxia. Moderate anemic hypoxia caused by blood dilution with polyglucine was easily compensated. Hb solution can be considered as the basis or the first stage in the production of an oxygen carrier blood substitute.
对两组猫的血液循环和呼吸的基础值进行了比较。第一组动物的血液被完全不含基质和促凝血活性的8%人血红蛋白溶液所替代。在第二组动物中，血液用聚葡萄糖稀释至血红蛋白水平为8 g%。该溶液在肺中充分饱和并向组织释放氧气，但比红细胞中的血红蛋白释放的氧气少得多。溶解的血红蛋白不能完全满足机体对氧气的需求，从而导致缺氧。用聚葡萄糖进行血液稀释引起的中度贫血性缺氧很容易得到代偿。血红蛋白溶液可被视为制备氧载体血液替代品的基础或第一阶段。
