Smirnov A N, Smirnova O V, Shul'gina N K, Rozen V B
Biull Eksp Biol Med. 1978 Aug;86(8):233-5.
Estradiol (E2) binding proteins from the liver cytoso-of mature male and female rats, mice, guinea pigs, and rabbits were investigated by gel filtration on Sepharose 6B columns. Components with Stokes radii (a) 6--7 and 2.5 nm which form specific stable complexes with E2 were found in female rats and female and male mice. The liver of male rats and male and female guinea pigs contain specific E2-binding proteins with a-about 6--7, 2.5 and less than 2.0 nm. E2 complexes with components having a values 6--7 and less than 2.0 nm relatively stable, whereas E2 complex with a component possessing a value about 2.5 nm is capable of dissociating completely within 45 minutes. It is suggested that at least some of the components of the discovered heterogenic populations of E2-binding proteins could participate in the estrogen signal reception by the liver.
通过在琼脂糖6B柱上进行凝胶过滤，对成熟雄性和雌性大鼠、小鼠、豚鼠及兔子肝脏胞质溶胶中的雌二醇（E2）结合蛋白进行了研究。在雌性大鼠以及雌性和雄性小鼠中发现了斯托克斯半径（a）为6 - 7和2.5纳米的成分，它们与E2形成特定的稳定复合物。雄性大鼠以及雄性和雌性豚鼠的肝脏含有特定的E2结合蛋白，其a约为6 - 7、2.5和小于2.0纳米。E2与a值为6 - 7和小于2.0纳米的成分形成的复合物相对稳定，而E2与a值约为2.5纳米的成分形成的复合物能够在45分钟内完全解离。有人提出，所发现的E2结合蛋白异质群体的至少某些成分可能参与肝脏对雌激素信号的接收。
