Smirnova O V, Smirnov A N, Rozen V B
Biull Eksp Biol Med. 1977 May;83(5):548-51.
Marked sex differences in estradiol-binding capacity ratio of components with Stokes radii (a) 7.0 and 2.5 nm in the liver cytosol of mature intact rats were found to be diminished, but not fully eliminated by gonadectomy. Prolonged administration of estradiol (50 microgram/animal for 8 days) to gonadectomized rats led to inhibition of the estradiol-binding activity of all the components in the liver cytosol of male and female animals. Administration of testosterone-propionate (2 mg/animal for 8 days) to gonadectomized animals stimulated selectivity the peculair estrogen-binding protein with a 2.5 nm not only in male, in which this protein was normally found, but also in female rats. It is supposed that sex differences in the system of estradiol-binding proteins in rat liver cytosol are determined by sex differentiation of the system at the early stages of ontogenesis, on the one hand, and by the active regulating influence of estrogens and androgens at the late stages of ontogenesis, on the other hand.
在成熟未阉割大鼠的肝脏胞质溶胶中，斯托克斯半径（a）为7.0和2.5纳米的组分的雌二醇结合能力比存在显著的性别差异，结果发现，性腺切除术可使这种差异减小，但不能完全消除。对去势大鼠长期给予雌二醇（50微克/只，持续8天）会抑制雄性和雌性动物肝脏胞质溶胶中所有组分的雌二醇结合活性。对去势动物给予丙酸睾酮（2毫克/只，持续8天）不仅会选择性刺激雄性动物（正常情况下可发现这种蛋白）中具有2.5纳米斯托克斯半径的特殊雌激素结合蛋白，还会刺激雌性大鼠中的该蛋白。据推测，大鼠肝脏胞质溶胶中雌二醇结合蛋白系统的性别差异一方面由个体发育早期该系统的性别分化决定，另一方面由个体发育后期雌激素和雄激素的主动调节作用决定。
