Hall M M, Gurchinoff S, Khosla M C, Khairallah P A
Blood Vessels. 1978;15(5):299-310. doi: 10.1159/000158175.
Structurally different inhibitors of prostaglandin synthesis reversed the antagonistic activity of the angiotensin II analog 1-sarcosine, 8-threonine angiotensin II. In isolated rabbit aorta, indomethacin or ETYA (eicosa 5, 8, 11, 14, tetraynoic) reversed the antagonism of the angiotensin II analog without affecting the dose response curves to angiotensin II. Both indomethacin and ETYA were able to reverse the tachyphylaxis to angiotensin II. Investigating the possibility that indomethacin could affect the binding of angiotensin II, it was found that at doses of indomethacin higher than 10(-5)M, binding of tritiated angiotensin to isolated adrenal cortical cells was reduced. It is postulated that indomethacin may have more than one effect on angiontensin, possessing a concentration-dependent effect on binding and prostaglandin synthesis.
结构不同的前列腺素合成抑制剂可逆转血管紧张素II类似物1-肌氨酸、8-苏氨酸血管紧张素II的拮抗活性。在离体兔主动脉中，吲哚美辛或ETYA（5,8,11,14-二十碳四炔酸）可逆转血管紧张素II类似物的拮抗作用，而不影响对血管紧张素II的剂量反应曲线。吲哚美辛和ETYA均能逆转对血管紧张素II的快速耐受性。在研究吲哚美辛是否会影响血管紧张素II结合的可能性时，发现当吲哚美辛剂量高于10^(-5)M时，氚标记的血管紧张素与离体肾上腺皮质细胞的结合减少。据推测，吲哚美辛对血管紧张素可能有多种作用，对结合和前列腺素合成具有浓度依赖性作用。
