Roberts A M, Messina E J, Kaley G
Prostaglandins. 1977 Jul;14(1):133-43. doi: 10.1016/0090-6980(77)90162-9.
Angiotensin-induced prostaglandin release has been implicated in the deveolpment of tachyphylaxis to angiotensin in vitro. Based on these findings and evidence that prostaglandins modulate the angiotensin reposne locally, experiments were done to investigate the role of prostaglandins in the systemic tachyphylaxis to angiotensin. Rats were given intravenous infusions of 1-asparaginyl-5-valyl and 1-aspartyl-5-isoleucyl andiotensin II at two different doses. Using systemic blood pressure as a parameter, varying degrees of tachyphylaxis were produced and the aspartyl analog was found to be more tachyphylactic. When rats were given indomethacin, a prostaglading synthesis inhibitors, the response to intravenous infusion of aspartyl angiotensin was not significantly altered.
血管紧张素诱导的前列腺素释放与体外对血管紧张素快速耐受性的发展有关。基于这些发现以及前列腺素在局部调节血管紧张素反应的证据，进行了实验以研究前列腺素在对血管紧张素的全身快速耐受性中的作用。给大鼠静脉输注两种不同剂量的1-天冬酰胺基-5-缬氨酰和1-天冬氨酰-5-异亮氨酰血管紧张素II。以体循环血压为参数，产生了不同程度的快速耐受性，并且发现天冬氨酰类似物的快速耐受性更强。当给大鼠服用吲哚美辛（一种前列腺素合成抑制剂）时，对静脉输注天冬氨酰血管紧张素的反应没有明显改变。
