分组与隔离对大鼠松果体切除诱发癫痫发作的影响。
Effects of grouping and isolation on pinealectomy-induced seizures in rats.
作者信息
Stockmeier C A, Blask D E
出版信息
Physiol Behav. 1983 Apr;30(4):651-2. doi: 10.1016/0031-9384(83)90237-8.
This study was undertaken to compare the effects of isolation versus grouping on pinealectomy (Px)-induced seizures in partially-parathyroidectomized (PTx) rats. Isolated rats (one per cage) experienced less than half the number of convulsions as those grouped six per cage. Furthermore, the time to the onset of the first seizure was more than doubled in isolated versus grouped rats. However, despite these differences, the number of rats convulsing per number at risk and the behavioral characteristics of the seizures of both isolated and grouped rats were virtually the same. This study shows that the method of caging dramatically affects certain aspects of Px-induced convulsions in partially-parathyroidectomized rats.
本研究旨在比较隔离饲养与群居饲养对部分甲状旁腺切除（PTx）大鼠松果体切除（Px）诱发癫痫发作的影响。隔离饲养的大鼠（每笼1只）惊厥次数不到群居饲养大鼠（每笼6只）的一半。此外，隔离饲养的大鼠首次癫痫发作的起始时间是群居饲养大鼠的两倍多。然而，尽管存在这些差异，但按风险计算每只惊厥大鼠的数量以及隔离饲养和群居饲养大鼠癫痫发作的行为特征实际上是相同的。本研究表明，饲养方式对部分甲状旁腺切除大鼠Px诱发惊厥的某些方面有显著影响。
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