3-氨基吡啶和4-氨基吡啶对血管收缩反应的增强作用。
Potentiation of vasoconstrictor responses by 3- and 4-aminopyridine.
作者信息
Glover W E
出版信息
Br J Pharmacol. 1978 Aug;63(4):577-85. doi: 10.1111/j.1476-5381.1978.tb17269.x.
Abstract
- In concentrations that are known to reduce potassium conductance in many excitable membranes, 3 and 4-aminopyridine (3-AP, 4-AP) potentiate vasoconstrictor responses of the isolated ear artery of the rabbit to noradrenaline and histamine. 2. 3- and 4-AP have no effect on the responses of potassium-depolarized arteries to noradrenaline, histamine or calcium. 3. The results suggest that the aminopyridines have no direct effect on the contractile machinery or on pharmacomechanical coupling, but cause potentiation by influencing electrical events at the cell membrane. 4. 4-AP causes a greater potentiation of the response te electrical stimulation than of the response to noradrenaline. This suggests that the aminopyridines may also cause an increase in the amount of noradrenaline released in response to sympathetic nerve stimulation.
摘要
- 3-氨基吡啶（3-AP）和4-氨基吡啶（4-AP）在已知能降低许多可兴奋膜钾电导的浓度下，可增强家兔离体耳动脉对去甲肾上腺素和组胺的血管收缩反应。2. 3-AP和4-AP对钾去极化动脉对去甲肾上腺素、组胺或钙的反应无影响。3. 结果表明，氨基吡啶对收缩机制或药理机械偶联无直接作用，而是通过影响细胞膜的电活动引起增强作用。4. 4-AP对电刺激反应的增强作用大于对去甲肾上腺素反应的增强作用。这表明氨基吡啶也可能导致交感神经刺激时释放的去甲肾上腺素量增加。
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