Kraemer R, Wiese G, Albertini M, Baghriche M, Geubelle F
Respir Physiol. 1983 May;52(2):229-44. doi: 10.1016/0034-5687(83)90008-7.
In order to evaluate the elastic properties of the lungs in children, a new exponential sigmoid curve fitting model was developed with the function VL = Vm + (Vm/1 + b X e-K X Pst), where VL is the lung volume, Pst the static recoil pressure, VM and Vm the upper and the lower asymptotes (limits of lung volume) and K and b are specific constants. Pressure-volume (PV) data obtained from tidal breathing cycles at different inflation and deflation levels from functional residual capacity (FRC) up to approximately 90% total lung capacity (TLC) in 16 healthy children have been evaluated by this model. K in relation to age, calculated by the least square nonlinear regression analysis decreased during childhood, whereas in b increased. It seems that K (a volume-independent index of compliance and alveolar distensibility) is influenced by the increasing number of elastic fiber bundles, changes in the surface/volume ratio and finally by changes in the composition of the surfactant. It can be seen that this model is not only restricted to higher lung volumes, the lower limb of the S-shaped curve is also represented.
为了评估儿童肺部的弹性特性，开发了一种新的指数型S形曲线拟合模型，其函数为VL = Vm + (Vm / 1 + b X e-K X Pst)，其中VL是肺容积，Pst是静态回缩压力，VM和Vm是上下渐近线（肺容积极限），K和b是特定常数。该模型评估了16名健康儿童在从功能残气量（FRC）到大约90%肺总量（TLC）的不同充气和放气水平下，潮气呼吸周期获得的压力-容积（PV）数据。通过最小二乘非线性回归分析计算得出的与年龄相关的K在儿童期下降，而b增加。似乎K（一个与容积无关的顺应性和肺泡扩张性指标）受弹性纤维束数量增加、表面/容积比变化以及最终表面活性剂成分变化的影响。可以看出，该模型不仅适用于较高肺容积，还能体现S形曲线的下肢部分。
