Knudson R J, Kaltenborn W T
Respir Physiol. 1981 Oct;46(1):29-42. doi: 10.1016/0034-5687(81)90066-9.
Static deflation pressure-volume curves for the lungs of 104 subjects were satisfactorily fitted to an exponential function, V = Vmax - Ae-kP (where Vmax is volume V extrapolated to infinite transpulmonary pressure P, and A and k are constants). Subjects included 48 who met rigorous criteria defining normal, 35 were PiM phenotype for alpha-1-antitrypsin deficiency and 21 were PiMZ phenotype. The shape constant k was significantly related to age, whereas an index of curve position was not. Values for k corresponded closely to the data of other investigators suggesting that it was independent of size and insensitive to differences in experimental technique. Elevated values of k, indicative of emphysema, were no more prevalent among PiMZ subjects than among subjects with no alpha-1-anti-trypsin deficiency. The natural logarithm (1n) of k, rather than k itself, appears to provide a useful, normally distributed, expression of lung distensibility.
对104名受试者肺部的静态放气压力-容积曲线进行拟合，结果令人满意地符合指数函数V = Vmax - Ae - kP（其中Vmax是外推至无限跨肺压P时的容积V，A和k为常数）。受试者包括48名符合严格正常标准的人，35名是α1抗胰蛋白酶缺乏症的PiM表型，21名是PiMZ表型。形状常数k与年龄显著相关，而曲线位置指数则不然。k值与其他研究者的数据密切对应，表明它与大小无关，对实验技术差异不敏感。k值升高表明患有肺气肿，在PiMZ受试者中并不比没有α1抗胰蛋白酶缺乏症的受试者更普遍。k的自然对数（ln），而非k本身，似乎提供了一种有用的、呈正态分布的肺扩张性表达。
