Foley M E, Griffin B D, Zuzel M, Aparicio S R, Bradbury K, Bird C C, Clayton J K, Jenkins D M, Scott J S, Rajah S M, McNichol G P
Br Med J. 1978 Jul 29;2(6133):322-4. doi: 10.1136/bmj.2.6133.322.
Uterine fluid was collected from a group of normal patients and a group of patients with menorrhagia. Heparin-like activity was detected in 34 out of 38 samples using an anti-Xa heparin assay. The heparin-like activity in uterine fluid was inhibited by adding the heparin antagonist hexadimethrine bromide to the assay. Concentrations of fibrinogen-fibrin degradation products (FDPs) were measured in five samples of uterine fluid. FDPs in the concentration detected had no effect on the anti-Xa assay. Heparin-like activity was higher in the group with menorrhagia, although the differences were not significant. Heparin-like activity increased throughout the menstrual cycle and decreased during menstruation, suggesting a possible cyclical variation in activity. There was no correlation between mast cell numbers in the endometrium and myometrium and heparin-like activity in uterine fluid and no correlation between the numbers and the stage in the menstrual cycle. In a few patients with intrauterine contraceptive devices (IUCDs) heparin-like activity was increased.
从一组正常患者和一组月经过多患者中收集子宫液。使用抗Xa肝素测定法在38个样本中的34个中检测到肝素样活性。通过在测定中加入肝素拮抗剂溴化己二甲铵来抑制子宫液中的肝素样活性。在五个子宫液样本中测量纤维蛋白原 - 纤维蛋白降解产物（FDPs）的浓度。检测到的浓度的FDPs对抗Xa测定没有影响。月经过多组的肝素样活性较高，尽管差异不显著。肝素样活性在整个月经周期中增加，在月经期间降低，表明活性可能存在周期性变化。子宫内膜和肌层中的肥大细胞数量与子宫液中的肝素样活性之间没有相关性，并且数量与月经周期阶段之间也没有相关性。在少数使用宫内节育器（IUCD）的患者中，肝素样活性增加。
