Golladay E S, Mollitt D L
South Med J. 1983 Aug;76(8):954-7, 961. doi: 10.1097/00007611-198308000-00002.
Over a five-year period, we treated 16 children ranging in age from 8 weeks to 16 years for ovarian masses. The most frequent clinical manifestation was abdominal pain and/or mass. Ultrasonography correctly localized the lesion and delineated its nature in nine of ten cases. Operation in 15 showed teratoma (six benign, two malignant), endodermal sinus tumor (two), dysgerminoma (two), follicular cyst (two), and leukemic ovarian infiltrate (one). Adnexal torsion was present in three. Three children had tumor metastases at initial operation. Resection of the tumor with conscious preservation of uninvolved pelvic structures was performed if possible. For unresectable tumor, debulking was undertaken. Multiagent chemotherapy was used for all malignant tumors. Survival was 94%. The proper therapy for ovarian lesions in children requires familiarity with the unique nature of these lesions, as well as consideration of future endocrine and reproductive function.
在五年时间里,我们对年龄从8周大到16岁的16名患有卵巢肿块的儿童进行了治疗。最常见的临床表现是腹痛和/或肿块。超声检查在十分之九的病例中正确定位了病变并明确了其性质。15例接受手术的病例显示为畸胎瘤(6例良性,2例恶性)、内胚窦瘤(2例)、无性细胞瘤(2例)、滤泡囊肿(2例)和白血病卵巢浸润(1例)。3例存在附件扭转。3名儿童在初次手术时有肿瘤转移。如果可能,在有意识地保留未受累盆腔结构的情况下进行肿瘤切除。对于无法切除的肿瘤,进行减瘤手术。所有恶性肿瘤均采用多药化疗。生存率为94%。儿童卵巢病变的恰当治疗需要熟悉这些病变的独特性质,同时考虑未来的内分泌和生殖功能。