Stamm A M, Phillips E K
South Med J. 1983 Aug;76(8):964-5. doi: 10.1097/00007611-198308000-00005.
Optimal antimicrobial therapy for viridans streptococcal endocarditis remains controversial. Rifampin was bactericidal at less than 0.2 micrograms/ml for ten strains of viridans streptococci isolated from patients with endocarditis. Administration of rifampin to one endocarditis patient already receiving penicillin and gentamicin increased the serum bactericidal activity fourfold. Rifampin has been effective in combination therapy for serious staphylococcal and enterococcal infections. The combination of penicillin and rifampin may be an effective, less toxic alternative to penicillin and streptomycin for the treatment of viridans streptococcal endocarditis.
草绿色链球菌心内膜炎的最佳抗菌治疗仍存在争议。利福平对从心内膜炎患者分离出的10株草绿色链球菌，在浓度低于0.2微克/毫升时具有杀菌作用。对一名已接受青霉素和庆大霉素治疗的心内膜炎患者加用利福平后，血清杀菌活性提高了四倍。利福平在严重葡萄球菌和肠球菌感染的联合治疗中已显示有效。青霉素和利福平联合使用，可能是治疗草绿色链球菌心内膜炎的一种有效且毒性较小的替代方案，可替代青霉素和链霉素。
