Yoshikawa T, Murakami M, Furukawa Y, Kato H, Takemura S, Kondo M
Thromb Haemost. 1983 Jun 28;49(3):214-6.
The experimental model of disseminated intravascular coagulation (DIC) in rats induced by a 4 hr sustained infusion of 100 mg/kg endotoxin was used to study the relationship between lipid peroxidation and DIC. Serum thiobarbituric acid (TBA) reactive substances, important and damaging products of lipid peroxidation, increased gradually during the infusion of endotoxin. The levels of TBA reactants in serum, abdominal aortic wall and ileum mucosa were significantly increased in rats infused with 100 mg/kg of endotoxin for 4 hr, as compared with the control rats continuously given 11.4 ml of physiological saline for 4 hr. However, the levels in liver and kidney tissues, and in gastric, jejunum and colon mucosa did not increase significantly.
采用持续4小时输注100mg/kg内毒素诱导大鼠弥散性血管内凝血（DIC）的实验模型，研究脂质过氧化与DIC之间的关系。血清硫代巴比妥酸（TBA）反应性物质是脂质过氧化的重要损伤产物，在内毒素输注过程中逐渐增加。与连续4小时给予11.4ml生理盐水的对照大鼠相比，输注100mg/kg内毒素4小时的大鼠血清、腹主动脉壁和回肠黏膜中的TBA反应物水平显著升高。然而，肝、肾组织以及胃、空肠和结肠黏膜中的水平没有显著升高。
