Ruitenberg E J, Buys J, Elgersma A, Teppema J S
Tijdschr Diergeneeskd. 1983 Jun 15;108(12):488-91.
The origin, kinetics and role of eosinophilic granulocytes in immune defense and inflammatory response in parasitism are reviewed. Particular attention was paid to the toxic action of eosinophilic granulocytes on parasites and the biochemical reactions which are of importance in these cases. Reference was also made to the regulatory role of eosinophilic granulocytes in inflammatory reactions, particularly in regard to mast cells. It was concluded that (1) several new insights into the role of eosinophilic granulocytes were gained in recent years, (2) that these cells can at any rate be said to have a dual function (viz. a directly parasitotoxic and regulatory role) and (3) a definite statement regarding the role of eosinophilic granulocytes in helminthic infections cannot so far be made.
本文综述了嗜酸性粒细胞在寄生虫感染的免疫防御和炎症反应中的起源、动力学及作用。特别关注了嗜酸性粒细胞对寄生虫的毒性作用以及在这些情况下具有重要意义的生化反应。还提及了嗜酸性粒细胞在炎症反应中的调节作用，尤其是对肥大细胞的调节作用。得出的结论是：（1）近年来对嗜酸性粒细胞的作用有了一些新的认识；（2）无论如何可以说这些细胞具有双重功能（即直接的抗寄生虫毒性和调节作用）；（3）目前尚无法对嗜酸性粒细胞在蠕虫感染中的作用做出明确的表述。
