Czarnetzki B M, Pawelzik B
Fortschr Med. 1983 Dec 15;101(47-48):2167-74.
Recent findings have contributed substantially to a better understanding of the ontogeny and function of eosinophil leukocytes. Together with other granulocytes, the cells originate in the bone marrow from a common stem cell. Their development is regulated by genetic factors and by products of T-lymphocytes. Chemotactic factors of the complement cascade (C5a), lymphokines and eosinophil chemotactic leukotrienes (ECL) stimulate their migration to tissue sites. Generation and biological effectiveness of eosinophil chemotactic factors can be modulated in numerous ways, thus changing the outcome of the inflammatory event. The probably most important effector function of eosinophils is their cytotoxicity which plays a role in the killing of parasites. Markedly elevated numbers of eosinophils can, however, cause auto-aggression against the body's own cells, such as the Purkinje cells of the brain, cardiac muscle cells or epithelial cells of the skin and the bronchial tree. Eosinophils are therefore cells capable of both serving and damaging the human host.
最近的研究结果极大地促进了对嗜酸性粒细胞的个体发生和功能的更好理解。与其他粒细胞一样，这些细胞起源于骨髓中的一个共同干细胞。它们的发育受遗传因素和T淋巴细胞产物的调节。补体级联反应的趋化因子（C5a）、淋巴因子和嗜酸性粒细胞趋化白三烯（ECL）刺激它们迁移到组织部位。嗜酸性粒细胞趋化因子的产生和生物学效应可以通过多种方式进行调节，从而改变炎症事件的结果。嗜酸性粒细胞可能最重要的效应功能是它们的细胞毒性，这在杀死寄生虫中起作用。然而，嗜酸性粒细胞数量的显著增加可导致对人体自身细胞的自身攻击，如大脑的浦肯野细胞、心肌细胞或皮肤和支气管树的上皮细胞。因此，嗜酸性粒细胞是既能为人类宿主服务又能对其造成损害的细胞。
