Larsson M, Forsman A
Ther Drug Monit. 1983 Jun;5(2):225-8. doi: 10.1097/00007691-198306000-00014.
A new high-performance liquid chromatographic method for the assay of perphenazine and its dealkylated metabolite is presented. The procedure is based on the use of thiethylperazine maleate as internal standard. Concentrations of perphenazine and its dealkylated metabolite could be analysed simultaneously in serum from patients being treated with the drug. The intraassay variability was 6.5% and 8.5% and the interassay variability 8.9% and 11.1% for drug and metabolite, respectively.
本文介绍了一种用于测定奋乃静及其脱烷基代谢物的新型高效液相色谱法。该方法以马来酸硫乙拉嗪作为内标。使用该药物治疗的患者血清中的奋乃静及其脱烷基代谢物的浓度能够同时进行分析。药物和代谢物的批内变异系数分别为6.5%和8.5%，批间变异系数分别为8.9%和11.1%。
