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治疗剂量后气相色谱法测定人血浆中奋乃静及其亚砜代谢物

Determination of perphenazine and its sulphoxide metabolite in human plasma after therapeutic doses by gas chromatography.

作者信息

Larsen N E, Naestoft J

出版信息

J Chromatogr. 1975 Jun 18;109(2):259-64. doi: 10.1016/s0021-9673(01)91797-2.

DOI:10.1016/s0021-9673(01)91797-2
PMID:1150819
Abstract

A gas chromatographic method for the determination of perphenazine (Tri-lafon) and its main metabolite in human plasma, perphenazine sulphoxide, has been developed. The procedure involves the use of an electron capture detector and permits the determination of the drug and its metabolite at concentrations down to 0.2 mug/l. This is sufficient for analyzing plasma from patients on ordinary treatment with perphenazine. Tests for specificity revealed no interference by nortriptyline or biperidine.

摘要

已开发出一种气相色谱法，用于测定人血浆中的奋乃静（三氟拉嗪）及其主要代谢物奋乃静亚砜。该方法采用电子捕获检测器，可测定低至0.2微克/升浓度的药物及其代谢物。这足以分析接受奋乃静常规治疗患者的血浆。特异性测试表明，去甲替林或比哌立登无干扰。

相似文献

1
Determination of perphenazine and its sulphoxide metabolite in human plasma after therapeutic doses by gas chromatography.治疗剂量后气相色谱法测定人血浆中奋乃静及其亚砜代谢物
J Chromatogr. 1975 Jun 18;109(2):259-64. doi: 10.1016/s0021-9673(01)91797-2.
2
Gas chromatographic determination of amitriptyline, nortriptyline and perphenazine in plasma of schizophrenic patients after administration of the combination of amitriptyline with perphenazine.气相色谱法测定精神分裂症患者服用阿米替林与奋乃静联合制剂后血浆中阿米替林、去甲替林和奋乃静的含量。
Arzneimittelforschung. 1979;29(1):158-61.
3
Plasma concentrations of perphenazine and its sulphoxide metabolite during continuous oral treatment.连续口服治疗期间奋乃静及其亚砜代谢物的血浆浓度。
Psychopharmacology (Berl). 1977 Jul 18;53(2):127-30. doi: 10.1007/BF00426481.
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A high-performance liquid chromatographic method for the assay of perphenazine and its dealkylated metabolite in serum after therapeutic doses.一种用于测定治疗剂量后血清中奋乃静及其脱烷基代谢物的高效液相色谱法。
Ther Drug Monit. 1983 Jun;5(2):225-8. doi: 10.1097/00007691-198306000-00014.
5
Gas-chromatographic analysis for therapeutic concentrations of amitriptyline and nortriptyline in plasma, with use of a nitrogen detector.使用氮检测器对血浆中阿米替林和去甲替林的治疗浓度进行气相色谱分析。
Clin Chem. 1976 Jun;22(6):777-81.
6
Perphenazine concentrations in human whole blood. A pilot study during anti-psychotic therapy using different administration forms.人全血中的奋乃静浓度。一项使用不同给药形式的抗精神病治疗期间的初步研究。
Psychopharmacologia. 1974 Jun 18;37(1):31-6. doi: 10.1007/BF00426680.
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Effect of simultaneous treatment with low doses of perphenazine on plasma and urine concentrations of nortriptyline and 10-hydroxynortriptyline.
Eur J Clin Pharmacol. 1977 Jul 19;11(6):479-83. doi: 10.1007/BF00562943.
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Development and validation of a gas chromatographic-mass spectrometric method for quantitative determination of perphenazine in rabbit plasma after sublingual administration.
J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Sep 1;872(1-2):51-7. doi: 10.1016/j.jchromb.2008.07.010. Epub 2008 Jul 15.
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Interaction of perphenazine with the kinetics of nortriptyline.
Acta Pharmacol Toxicol (Copenh). 1977 Jan;40(1):97-105. doi: 10.1111/j.1600-0773.1977.tb02057.x.
10
Plasma levels of perphenazine and its major metabolites during simultaneous treatment with anticholinergic drugs.在与抗胆碱能药物同时治疗期间奋乃静及其主要代谢物的血浆水平。
Br J Clin Pharmacol. 1979 Jan;7(1):75-80. doi: 10.1111/j.1365-2125.1979.tb00900.x.

引用本文的文献

1
Gas chromatographic - mass spectrometric determination of dixyrazine in human blood.气相色谱-质谱法测定人血中的二苯西平
Eur J Clin Pharmacol. 1981;20(4):307-10. doi: 10.1007/BF00618782.
2
Radioimmunoassay for perphenazine in human plasma.人血浆中奋乃静的放射免疫测定法。
Br J Clin Pharmacol. 1981 Jan;11(1):85-8. doi: 10.1111/j.1365-2125.1981.tb01107.x.
3
Dose-response relationships of perphenazine in the treatment of acute psychoses.奋乃静治疗急性精神病的剂量-反应关系。
Psychopharmacology (Berl). 1982;78(2):112-5. doi: 10.1007/BF00432245.
4
Plasma levels of perphenazine (Trilafon) related to development of extrapyramidal side effects.与锥体外系副作用发生相关的奋乃静（三氟拉嗪）血浆水平。
Psychopharmacology (Berl). 1981;74(4):306-9. doi: 10.1007/BF00432736.
5
Antipsychotic drugs. Clinical pharmacokinetics of potential candidates for plasma concentration monitoring.抗精神病药物。血浆浓度监测潜在候选药物的临床药代动力学。
Clin Pharmacokinet. 1987 Aug;13(2):65-90. doi: 10.2165/00003088-198713020-00001.
6
Clinical pharmacokinetic studies of perphenazine.奋乃静的临床药代动力学研究。
Br J Clin Pharmacol. 1976 Oct;3(5):915-23. doi: 10.1111/j.1365-2125.1976.tb00647.x.
7
Plasma levels of perphenazine and its major metabolites during simultaneous treatment with anticholinergic drugs.在与抗胆碱能药物同时治疗期间奋乃静及其主要代谢物的血浆水平。
Br J Clin Pharmacol. 1979 Jan;7(1):75-80. doi: 10.1111/j.1365-2125.1979.tb00900.x.
8
Plasma concentrations of perphenazine and its sulphoxide metabolite during continuous oral treatment.连续口服治疗期间奋乃静及其亚砜代谢物的血浆浓度。
Psychopharmacology (Berl). 1977 Jul 18;53(2):127-30. doi: 10.1007/BF00426481.
9
Effects of perphenazine enanthate injections on prolactin levels in plasma from schizophrenic women and men.庚酸奋乃静注射液对精神分裂症女性和男性血浆中催乳素水平的影响。
Psychopharmacology (Berl). 1978 Apr 14;57(1):1-4. doi: 10.1007/BF00426949.