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在一名分娩出未受影响婴儿的初产妇中,与自身免疫性溶血性贫血相关的模拟抗-Jkb加抗-Jk3的自身抗体。

Autoantibodies mimicking anti-Jkb plus anti-Jk3 associated with autoimmune hemolytic anemia in a primipara who delivered an unaffected infant.

作者信息

Ellisor S S, Reid M E, O'Day T, Swanson J, Papenfus L, Avoy D R

出版信息

Vox Sang. 1983;45(1):53-9. doi: 10.1111/j.1423-0410.1983.tb04122.x.

DOI:10.1111/j.1423-0410.1983.tb04122.x
PMID:6880145
Abstract

A serum sample from a nontransfused 25-year-old Caucasian primipara contained weak anti-Jkb plus anti-Jk3. The direct antiglobulin test on the patient's red cells was strongly positive. Anti-Jkb was recovered in a heat eluate. An ether eluate contained anti-Jk3. Her red cells types as Jk(a-b+)Jk:3. The anti-Jkb and anti-Jk3 reactivity was completely absorbed both by red cell samples lacking and red cells possessing the corresponding antigens, indicating these antibody specificities to be of the mimicking variety. At 41 weeks gestation she delivered a normal, healthy infant with no detectable serum or cell bound antibody.

摘要

一名25岁未输血的白种初产妇的血清样本中含有弱抗-Jkb和抗-Jk3。对患者红细胞进行的直接抗球蛋白试验呈强阳性。抗-Jkb在热洗脱液中被回收。乙醚洗脱液中含有抗-Jk3。她的红细胞血型为Jk(a-b+)Jk:3。抗-Jkb和抗-Jk3反应性被缺乏相应抗原的红细胞样本和含有相应抗原的红细胞样本完全吸收,表明这些抗体特异性属于模拟型。妊娠41周时,她产下一名正常、健康的婴儿,未检测到血清或细胞结合抗体。

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