直接抗球蛋白试验阴性的Evans综合征中的自身抗Jka抗体
Auto-anti-Jka in Evans' syndrome with negative direct antiglobulin test.
作者信息
Ganly P S, Laffan M A, Owen I, Hows J M
机构信息
Department of Haematology, Royal Postgraduate Medical School, Hammersmith Hospital, London.
出版信息
Br J Haematol. 1988 Aug;69(4):537-9. doi: 10.1111/j.1365-2141.1988.tb02411.x.
A patient presented with haemolytic anaemia and a negative direct antiglobulin test (DAT), and was found to have an IgG antibody with anti-Jka specificity in his serum. His red cells were typed as Jk(a-b+). Later he developed idiopathic thrombocytopenic purpura (ITP), and had a positive DAT due to anti-Jka bound to his red cells, which now typed as Jk(a+b+). Family studies suggested that the patient's true type was Jk(a+b+). Splenectomy and immunosuppression were required to treat the thrombocytopenia. The autoanti-Jka was no longer detectable following therapy.
一名患者出现溶血性贫血，直接抗球蛋白试验（DAT）呈阴性，其血清中发现有一种具有抗Jka特异性的IgG抗体。他的红细胞血型为Jk(a-b+)。后来他患上了特发性血小板减少性紫癜（ITP），由于抗Jka抗体结合在其红细胞上，DAT呈阳性，此时红细胞血型为Jk(a+b+)。家族研究表明该患者的真实血型为Jk(a+b+)。需要进行脾切除术和免疫抑制治疗血小板减少症。治疗后自身抗Jka抗体不再可检测到。
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