Shibata Y, Baba M, Kuniyuki M
Vox Sang. 1983;45(1):77-82. doi: 10.1111/j.1423-0410.1983.tb04126.x.
Catabolism of intravenously or intramuscularly administered human immunoglobulin in man was studied by the administration of HBs antibodies at a high titer and analysis with a highly sensitive radioimmunoassay technique. The half-life in the blood of the antibodies in the aggregate-reduced antibody preparation administered intravenously was found to be 17.7 days and of those in the antibody preparation administered intramuscularly to be 23.8 days.
通过给予高滴度的乙肝表面抗体（HBs抗体）并采用高灵敏度放射免疫分析技术进行分析，对人体中静脉内或肌肉内注射的人免疫球蛋白的分解代谢进行了研究。结果发现，静脉注射的聚合体减少型抗体制剂中抗体在血液中的半衰期为17.7天，而肌肉注射的抗体制剂中抗体的半衰期为23.8天。
