Partsch G, Tausch G, Neuwirth E, Neumüller J
Z Rheumatol. 1983 May-Jun;42(3):126-9.
The effect of D-penicillamine (DPA; 150 mg/day) on plasma amino acids administered to female patients suffering from rheumatoid arthritis (RA) was observed daily during the first 9 days of the treatment. A statistically significant influence of the oral DPA administration was detected. In comparison to control, a decrease in 12 out of 18 amino acids was found on day 2. Furthermore, for 6 amino acids an increase and a peak concentration on day 6 or 7 were observed. Surprisingly, similar results were also obtained in rats after oral application of DPA. These findings give further evidence for the multifactorial action of DPA.
在类风湿性关节炎（RA）女性患者治疗的前9天，每日观察D-青霉胺（DPA；150毫克/天）对血浆氨基酸的影响。检测到口服DPA具有统计学上的显著影响。与对照组相比，在第2天发现18种氨基酸中有12种减少。此外，观察到6种氨基酸在第6天或第7天增加并达到峰值浓度。令人惊讶的是，大鼠口服DPA后也获得了类似的结果。这些发现为DPA的多因素作用提供了进一步的证据。
