Lundell B P, Boréus L O
Acta Paediatr Scand. 1983 May;72(3):339-43. doi: 10.1111/j.1651-2227.1983.tb09725.x.
Left ventricular systolic time intervals were assessed in 16 preterm infants with symptomatic left-to-right ductal shunts, before, during and after digoxin therapy. An intravenous loading dose of digoxin, 20 micrograms/kg, resulted in a serum digoxin concentration of 1.94 +/- 0.44 nmol/l (mean +/- 1 SD) but in no significant change in heart rate or systolic time intervals. Digoxin maintenance, 2.5 micrograms/kg/12 h, led 3-7 days later to serum concentrations of 2.57 +/- 1.06 nmol/l with an associated shortening of left ventricular ejection time (p less than 0.05) which probably reflected a reduced ductal shunt. Digoxin therapy was withdrawn after ductal closure. The terminal serum half-life was 87 +/- 17 h. Decreasing digoxin concentrations were associated with prolongation of left ventricular ejection time (p less than 0.01). Digoxin therapy did not seem to influence left ventricular systolic time intervals while ductal patency persisted. This may be attributed to limitations of the method or the left ventricle already working at its maximum.
对16例有症状的左向右导管分流的早产儿在洋地黄治疗前、治疗期间和治疗后评估左心室收缩时间间期。静脉注射负荷剂量的地高辛，20微克/千克，导致血清地高辛浓度为1.94±0.44纳摩尔/升（均值±1标准差），但心率或收缩时间间期无显著变化。地高辛维持剂量为2.5微克/千克/12小时，3 - 7天后血清浓度为2.57±1.06纳摩尔/升，同时左心室射血时间缩短（p<0.05），这可能反映了导管分流减少。导管闭合后停用洋地黄治疗。终末血清半衰期为87±17小时。地高辛浓度降低与左心室射血时间延长有关（p<0.01）。在导管保持通畅期间，洋地黄治疗似乎并未影响左心室收缩时间间期。这可能归因于该方法的局限性或左心室已处于最大工作状态。
