McCraw B M, Slocombe J O
Can J Comp Med. 1978 Jul;42(3):340-56.
Pony foals inoculated with infective Strongylus edentatus larvae were examined at necropsy from ten to 72 weeks postinfection. At ten weeks postinfection larvae were visible retroperitoneally in the liver and flanks and were recovered from the ligaments of the liver. The fourth molt was detected at 16 weeks postinfection and larvae were also recovered from the wall of the cecum at this time. By 40 weeks adult S. edentatus containing eggs were found in the contents of the cecum and colon. While many larvae migrate to remote parts of the body, it is likely that only those that attain the base of the cecum are successful in establishing in the cecum and colon as adult forms. By 36 weeks postinfection no larvae were found in the liver and up to this time none were found in the peritoneal cavity. Larvae were not recovered from the parenchyma of the lungs. Adhesions and disruption of omental architecture were frequent changes observed throughout infection. Casts of necrotic eosinophils enclosing tracks and larvae were observed beneath the intima of major veins of the cecum and colon. The liver was rough and the capsule thickened at 16 and 20 weeks postinfection and the flanks remained edematous until 36 weeks postinfection.
对接种感染性无齿圆线虫幼虫的小马驹在感染后10至72周进行尸检。感染后10周，在肝脏和胁腹的腹膜后可见幼虫，并从肝脏韧带中回收。感染后16周检测到第四次蜕皮，此时也从盲肠壁回收了幼虫。到40周时，在盲肠和结肠内容物中发现了含卵的成年无齿圆线虫。虽然许多幼虫迁移到身体的偏远部位，但可能只有那些到达盲肠底部的幼虫才能成功地在盲肠和结肠中发育为成虫。感染后36周，肝脏中未发现幼虫，在此之前，腹腔中也未发现幼虫。未从肺实质中回收幼虫。在整个感染过程中，经常观察到网膜结构的粘连和破坏。在盲肠和结肠主要静脉内膜下方观察到包裹着虫道和幼虫的坏死嗜酸性粒细胞铸型。感染后16周和20周，肝脏粗糙，包膜增厚，胁腹水肿一直持续到感染后36周。
