Quiros G, Ware J
Acta Physiol Scand. 1983 Mar;117(3):397-403. doi: 10.1111/j.1748-1716.1983.tb00012.x.
Non-starved (fed) and starved rats, sedated with a neurolept analgesic, were subjected to 45 min of hemorrhagic hypotension. The hemorrhage inflicted did not cause hypoxic changes, and left fed and starved animals with the same residual blood volume. Fed animals developed a state of hyperglycemic hyperosmolality and their free fatty acids tended to rise, while these observations were modified among starved animals. After 15 min of hemorrhage the cardiovascular parameters were the same in fed and starved animals, but at 45 min striking differences were observed. In fed animals, cardiac output, stroke volume, skin and muscle flows were substantially higher than starved animal values, while the latter animals had a higher heart rate and peripheral resistance. These effects are attributed to the state of hyperosmolality developed by the fed animals, and can explain the association between nutritional status and survival in hemorrhage.
用神经安定镇痛药镇静的非饥饿（喂食）和饥饿大鼠，经历了45分钟的出血性低血压。造成的出血未引起缺氧变化，使喂食和饥饿动物的残余血容量相同。喂食动物出现高血糖高渗状态，其游离脂肪酸趋于升高，而在饥饿动物中这些观察结果有所改变。出血15分钟后，喂食和饥饿动物的心血管参数相同，但在45分钟时观察到显著差异。在喂食动物中，心输出量、每搏输出量、皮肤和肌肉血流量明显高于饥饿动物的值，而后者的心率和外周阻力较高。这些效应归因于喂食动物出现的高渗状态，并且可以解释营养状况与出血时存活率之间的关联。
