Miadonna A, Tedeschi A, Leggieri E, Cottini M, Restuccia M, Bianchini C
Ann Allergy. 1983 Aug;51(2 Pt 1):201-4.
Specific degranulation of mast cells and basophils depends upon transmembrane calcium flow. In the present studies the protective effect of the calcium-antagonist drug verapamil against allergen-induced asthma was assessed in eight atopic patients. The results of this study showed that verapamil, administered both orally or by aerosol, can prevent the specific bronchoconstriction.
肥大细胞和嗜碱性粒细胞的特异性脱粒取决于跨膜钙流。在本研究中，对8名特应性患者评估了钙拮抗剂维拉帕米对变应原诱发哮喘的保护作用。该研究结果表明，口服或通过气雾剂给药的维拉帕米均可预防特异性支气管收缩。
