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钙拮抗剂对人嗜碱性粒细胞组胺释放的影响。

Effect of calcium antagonists on histamine release from human basophil leukocytes.

作者信息

Miadonna A, Tedeschi A, Leggieri E, Lorini M, Froldi M, Zanussi C

出版信息

Br J Clin Pharmacol. 1986 Oct;22(4):483-6. doi: 10.1111/j.1365-2125.1986.tb02922.x.

DOI:10.1111/j.1365-2125.1986.tb02922.x
PMID:2429685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1401155/
Abstract

The effect of calcium antagonists on basophil activation was investigated in 14 subjects. Verapamil, methoxyverapamil and diltiazem, in a concentration range of 1-100 microM, exert a concentration-dependent inhibition on the human basophil histamine release induced by calcium ionophore A23187, zymosan activated human serum and grass pollen allergens. This inhibitory effect is highly variable from subject to subject and from drug to drug. At concentrations higher than 200 microM, verapamil, methoxyverapamil and diltiazem induce a calcium independent histamine secretion from basophil leukocytes. This mediator release is associated with an increase in LDH levels in the cell supernatant and seems to be due to a cytotoxic effect.

摘要

在14名受试者中研究了钙拮抗剂对嗜碱性粒细胞活化的影响。维拉帕米、甲氧维拉帕米和地尔硫䓬在1-100微摩尔浓度范围内，对钙离子载体A23187、酵母聚糖激活的人血清和草花粉过敏原诱导的人嗜碱性粒细胞组胺释放具有浓度依赖性抑制作用。这种抑制作用在不同受试者和不同药物之间差异很大。在高于200微摩尔的浓度下，维拉帕米、甲氧维拉帕米和地尔硫䓬可诱导嗜碱性白细胞分泌不依赖钙的组胺。这种介质释放与细胞上清液中乳酸脱氢酶水平的升高有关，似乎是由于细胞毒性作用。

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本文引用的文献

1
Effect of verapamil on allergen-induced asthma in patients with respiratory allergy.维拉帕米对呼吸道过敏患者变应原诱导性哮喘的影响。
Ann Allergy. 1983 Aug;51(2 Pt 1):201-4.
2
Uptake of calcium antagonistic drugs into muscles as related to their lipid solubilities.钙拮抗药物在肌肉中的摄取与其脂溶性的关系。
Biochem Pharmacol. 1984 Mar 1;33(5):821-6. doi: 10.1016/0006-2952(84)90468-4.
3
Inhibitory effect of calcium antagonists on histamine release from human leukocytes. In vivo and in vitro experiments.钙拮抗剂对人白细胞组胺释放的抑制作用。体内和体外实验。
Allergy. 1983 May;38(4):233-7. doi: 10.1111/j.1398-9995.1983.tb01616.x.
4
Dual effect of verapamil on rat peritoneal mast cells: inhibition or induction of histamine release.维拉帕米对大鼠腹膜肥大细胞的双重作用：抑制或诱导组胺释放。
Braz J Med Biol Res. 1982 Oct;15(4-5):269-73.
5
The mechanism of ketotifen-induced histamine release from human peripheral leucocytes.酮替芬诱导人外周血白细胞释放组胺的机制。
Int Arch Allergy Appl Immunol. 1982;68(2):176-8. doi: 10.1159/000233090.
6
Basophil "releasability" in patients with asthma.哮喘患者的嗜碱性粒细胞“释放能力”
Am Rev Respir Dis. 1980 Jul;122(1):53-9. doi: 10.1164/arrd.1980.122.1.53.
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Inhibition of allergic and non-allergic histamine secretion from rat peritoneal mast cells by calcium antagonists.钙拮抗剂对大鼠腹膜肥大细胞过敏和非过敏组胺分泌的抑制作用。
Br J Pharmacol. 1984 Dec;83(4):899-902. doi: 10.1111/j.1476-5381.1984.tb16529.x.
8
A sequence of biochemical events in the antigen-induced release of chemical mediators from sensitized human lung tissue.抗原诱导致敏人肺组织释放化学介质过程中的一系列生化事件。
J Exp Med. 1973 Nov 1;138(5):1077-94. doi: 10.1084/jem.138.5.1077.
9
Automated histamine analysis for in vitro allergy testing. I. A method utilizing allergen-induced histamine release from whole blood.用于体外过敏测试的组胺自动分析。I. 一种利用变应原诱导全血组胺释放的方法。
J Allergy Clin Immunol. 1976 Jun;57(6):525-40. doi: 10.1016/0091-6749(76)90003-8.

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