Tribukait B, Rönström L, Esposti P L
Anal Quant Cytol. 1983 Jun;5(2):107-11.
The cellular DNA content of fine needle aspirates from 300 patients with newly discovered, untreated prostatic carcinomas was measured by flow cytofluorometry. Well-differentiated tumors were mostly diploid or tetraploid aneuploid while poorly differentiated tumors were almost exclusively aneuploid, with a predominance of nontetraploid modal values. Moderately differentiated tumors exhibited either diploid or any aneuploid pattern. No multiple aneuploid cell lines were found in well-differentiated tumors, but the frequency increased with malignancy grade up to 21%. The proportion of aneuploid cells was significantly higher in nontetraploid tumors and increased with the malignancy grade. These results justify the subdivision of aneuploid prostatic tumors into cases with tetraploid and nontetraploid cell lines. The quantification of aneuploid cells may imply a new parameter in the biologic evaluation of these tumors.
通过流式细胞荧光测定法对300例新发现的未经治疗的前列腺癌患者细针穿刺抽吸物的细胞DNA含量进行了测量。高分化肿瘤大多为二倍体或四倍体非整倍体，而低分化肿瘤几乎全为非整倍体，以非四倍体众数为主。中分化肿瘤表现为二倍体或任何非整倍体模式。在高分化肿瘤中未发现多个非整倍体细胞系，但随着恶性程度增加频率上升至21%。非四倍体肿瘤中非整倍体细胞的比例显著更高，并随恶性程度增加。这些结果证明将非整倍体前列腺肿瘤细分为具有四倍体细胞系和非四倍体细胞系的病例是合理的。非整倍体细胞的定量可能意味着这些肿瘤生物学评估中的一个新参数。
