Anderson L M
Cancer Lett. 1978 Jul;5(1):55-9. doi: 10.1016/s0304-3835(78)80011-1.
Transplacental exposure of BALB/c mice to urethane on day 17 of gestation resulted in the appearance of 2 distinct crops of primary lung tumors (adenomas). The first, smaller crop occurred in 6--12% of the offspring by 12 weeks of age. The second crop, seen after 9 months of age, consisted of tumors in 45% of the offspring. This finding indicates a potentially useful model system for studying tumor latency. It also suggests caution in the choice of short endpoints in time carcinogenesis assays based on lung tumors in certain strains of mouse.
在妊娠第17天，将BALB/c小鼠经胎盘暴露于氨基甲酸乙酯，结果出现了两批不同的原发性肺肿瘤（腺瘤）。第一批较小的肿瘤在12周龄时出现在6% - 12%的后代中。第二批肿瘤出现在9个月龄之后，45%的后代出现了肿瘤。这一发现表明该模型系统对于研究肿瘤潜伏期可能有用。它还提示在基于某些品系小鼠肺肿瘤的时间致癌性试验中选择短期终点时要谨慎。
