Anderson L M, Budinger J M, Maronpot R R, Good R A
Cancer Res. 1978 Jan;38(1):137-41.
Female BALB/c nu/+ mice, pregnant by nu/+ males (nu: gene for hairlessness-athymia) were given injections of urethan, a transplacental tumorigen, on Day 17 or 19 of gestation. After an average of 16 weeks under clean conventional conditions, the incidence of primary lung tumors was similar in nude and normal offspring treated with carcinogen on either gestational day, with a higher incidence after treatment of Day 19. Thus, the absence of thymus did not affect the occurrence of transplacentally induced primary lung tumors or alter the well-known perinatal increase in sensitivity. Histologically, the nu/nu tumors differed from normal in the appearance of many atypical basophilic cells and in a tendency to invade both the parenchyma and the pleural surface. These results suggested progression of the lung adenomas to a more atypical, invasive form, a progression that may have occurred prematurely in the absence of thymus-dependent immune response.
雌性BALB/c裸杂合小鼠（nu/+），与nu/+雄性小鼠交配怀孕（nu：无毛-无胸腺基因），在妊娠第17天或第19天注射尿烷（一种经胎盘致癌剂）。在清洁常规条件下平均饲养16周后，在任一妊娠日接受致癌物处理的裸鼠和正常后代中，原发性肺肿瘤的发生率相似，在第19天处理后发生率更高。因此，胸腺缺失并不影响经胎盘诱导的原发性肺肿瘤的发生，也不会改变众所周知的围产期敏感性增加。组织学上，nu/nu肿瘤在许多非典型嗜碱性细胞的外观以及侵袭实质和胸膜表面的倾向方面与正常肿瘤不同。这些结果表明肺腺瘤进展为更不典型、侵袭性更强的形式，这种进展可能在缺乏胸腺依赖性免疫反应的情况下过早发生。
