Kuzin M I, Pomelov V S, Vandiaev G K, Ialgashev T Ia, Blatun L A
Antibiotiki. 1983 May;28(5):358-62.
The data on comparative study of complications after operations on the large intestine are presented. During the preoperative period, 62 patients of the control group were treated with phthalylsulfathiazole, nevigramon and nystatin. Thirty-nine patients of the test group were treated with metronidazole and kanamycin monosulfate. Kanamycin monosulfate was used 3 days before the operation in a dose of 0.5 g orally 4 times a day whereas metronidazole in a dose of 0.5 g 3 times a day. The last doses of the drugs were administered 4-5 hours before the operation. After the operations the patients were treated with kanamycin sulfate for 3-5 days in a daily dose of 2 g intramuscularly. The number of the postoperative suppurative complications decreased from 22 to 5 per cent. No lethal outcomes were registered in the test group. The number of lethal outcomes in the control group amounted to 8 per cent.
本文呈现了大肠手术后并发症的对比研究数据。术前，对照组的62例患者接受了酞磺胺噻唑、维生素U片和制霉菌素治疗。试验组的39例患者接受了甲硝唑和硫酸卡那霉素治疗。硫酸卡那霉素在手术前3天使用，剂量为0.5克，每日口服4次，而甲硝唑剂量为0.5克，每日3次。最后一剂药物在手术前4 - 5小时服用。术后，患者接受硫酸卡那霉素治疗3 - 5天，每日剂量为2克，肌肉注射。术后化脓性并发症的数量从22%降至5%。试验组未出现死亡病例。对照组的死亡病例数为8%。
